Atelvia Warnings and Precautions

When taking Atelvia, it's important to remain in an upright position for at least 30 minutes afterwards. If this is not possible for you, your healthcare provider may recommend a different osteoporosis drug. Precautions and warnings with Atelvia also apply to people who have problems with their esophagus, as well as those who need to undergo dental procedures.

What Should I Tell My Healthcare Provider?

Prior to taking Atelvia™ (risedronate delayed-release), talk with your healthcare provider if you have:
  • Low blood calcium (hypocalcemia)
  • An inability to sit upright or stand for 30 minutes
  • Kidney disease, including kidney failure (renal failure)
  • Difficulty swallowing or other problems with your esophagus
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding
  • Planning to have a dental procedure.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Atelvia

Warnings and precautions to be aware of prior to taking this drug include the following:
  • In rare cases, bisphosphonates (including Atelvia) have caused a condition called osteonecrosis of the jaw. This is a serious, possibly disfiguring, problem in which the bone of the jaw dies. Often, there are symptoms (such as pain, infection, or loosening of the teeth), but sometimes there are no symptoms until a person notices exposed bone.  
This problem is most common when bisphosphonates are given by IV, but is still possible when these medications are taken orally. People who have dental procedures such as a tooth extraction seem to be at higher risk. Be sure to take good care of your mouth and teeth by seeing your dentist frequently. Let your healthcare provider know right away if you think you may have osteonecrosis of the jaw. 
  • There have been rare reports of unusual broken thigh bones in people taking bisphosphonate medications like Atelvia. It is not yet clear if the medications are to blame, since the fractures could simply be due to osteoporosis or other factors. These fractures typically were not caused by trauma or injury. Let your healthcare provider know if you have unexplained groin or thigh pain, as these are sometimes signs of thigh fractures.
  • Atelvia, like all bisphosphonate medications, can irritate or damage the esophagus and stomach. This can lead to indigestion, heartburn, or even ulcers. Let your healthcare provider know if you notice any of these problems while taking the drug. Failing to remain upright for 30 minutes after an Atelvia dosage increases the risk of esophageal problems.
  • It is important to closely follow the instructions for taking Atelvia. Not doing so could increase your risk of side effects or may make the drug ineffective (see Atelvia Dosage for more information).
  • It is important that you get enough calcium and vitamin D while taking Atelvia, either through your diet or by supplementation. Calcium and vitamin D are necessary for rebuilding bone and preventing further bone loss, and Atelvia cannot work if you do not get enough of these substances. Also, taking calcium and vitamin D may help prevent low blood calcium.
  • This product may not be recommended for people with severe kidney disease.
  • Bisphosphonates can cause extreme muscle or bone pain. This usually goes away once the medication is stopped.
  • Atelvia can potentially react with a number of medications (see Atelvia Drug Interactions).
  • This drug is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy (see Atelvia and Pregnancy).
  • It is not known if Atelvia passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Atelvia and Breastfeeding).
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Atelvia Medication Information

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