Calcium Drug Interactions

Calcium Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when calcium is combined with any of the drugs listed above.
Although it is usually recommended to make sure you take enough calcium while taking a bisphosphonate, you should not take them both at the same time. Calcium can significantly decrease the absorption of bisphosphonates. It is best to take them at different times of the day.
Theoretically, taking calcium supplements while using calcipotriene skin cream can increase the risk of dangerously high calcium levels in the blood (hypercalcemia). It is generally recommended that people using calcipotriene avoid taking calcium supplements.
There have been reports of serious lung and kidney problems in newborns given both ceftriaxone (an injectable antibiotic) and intravenous calcium. Some deaths have occurred. Therefore, it is advised to avoid giving calcium by IV to anyone who has been given ceftriaxone in the previous 48 hours.
Calcium can bind to fluoroquinolone antibiotics in the digestive tract, significantly decreasing the absorption of the antibiotics. In general, it is advised to take fluoroquinolones at least two hours before or four to six hours after taking calcium (the recommendations may slightly vary among the different antibiotics). If you are taking the antibiotic for only a short period of time, it may be best to simply stop taking the calcium temporarily.
H2 Blockers
Low stomach acid levels due to taking H2 blockers can decrease the absorption of calcium. This problem can be reduced by taking calcium citrate instead of calcium carbonate, although taking either form of calcium with a meal may also work just as well (since food stimulates stomach acid production).
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