Calcium Drug Interactions

Levothyroxine
Calcium can bind to levothyroxine in the digestive tract, significantly decreasing the absorption of levothyroxine. In general, it is advised to separate these two products by at least four hours, in order to avoid this interaction.
 
Proton Pump Inhibitors (PPIs)
Low stomach acid levels due to taking PPIs can decrease the absorption of calcium. This problem can be reduced by taking calcium citrate instead of calcium carbonate, although taking either form of calcium with a meal may also work just as well (since food stimulates stomach acid production).
 
Sotalol
Calcium can bind to sotalol in the digestive tract, significantly decreasing the absorption of sotalol. In general, it is advised to take sotalol at least two hours before or four to six hours after taking calcium. Do not change the way you take sotalol in relation to calcium without first checking with your healthcare provider (since small changes in sotalol absorption can have drastic consequences).
 
Tetracyclines
Calcium can bind to tetracycline antibiotics in the digestive tract, significantly decreasing the absorption of the antibiotics. In general, it is advised to take tetracyclines at least two hours before or four to six hours after taking calcium (the recommendations may slightly vary among the different antibiotics). If you are taking the antibiotic for only a short period of time, it may be best to simply stop taking the calcium temporarily.
 
Thiazides
Thiazide diuretics decrease the amount of calcium that is excreted in the urine. Taking thiazide diuretics with calcium (especially large doses of calcium) may increase the risk of serious problems related to high calcium levels in the blood. If you take a thiazide diuretic, do not take calcium without first consulting with your healthcare provider. Your healthcare provider can recommend an appropriate calcium dosage for your individual situation.
 
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