Fosamax Plus D Drug Interactions

When certain medications are taken with Fosamax Plus D, drug interactions may occur that could lead to side effects or reduced effectiveness of the medicine. Some of the medications that may interact with Fosamax Plus D include iron supplements, thiazide diuretics, and aspirin. Foods and beverages can also cause Fosamax Plus D drug interactions, so be sure to take the medication on an empty stomach.

 

Fosamax Plus D Drug Interactions: An Overview

Fosamax Plus D™ (alendronate and cholecalciferol) can potentially interact with a number of other medications. Many interactions can make Fosamax Plus D less effective, while others may increase the risk of side effects. Some of the medicines that may lead to Fosamax Plus D drug interactions include:
 
  • Aspirin
  • Bile acid sequestrants, such as:
 
 
  • Calcium products, including many antacids
  • Cimetidine (Tagamet®)
  • Iron supplements
  • Magnesium products
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
Food and beverages (other than water) can also interact with Fosamax Plus D, preventing it from being absorbed into the body and making it less effective. Fosamax Plus D should be taken with plain water in the morning on an empty stomach. Do not eat or drink anything (besides water) before taking Fosamax Plus D and for 30 minutes after taking your Fosamax Plus D dosage.
 
(Fosamax Plus D Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;