Ipriflavone for Osteoporosis (Cont.)

Specifics Regarding Ipriflavone for Osteoporosis

Ipriflavone, a synthetic isoflavone, has shown some promise in its ability to preserve bone in postmenopausal women. Ipriflavone has also been shown to have a protective effect on bone density in premenopausal women taking the treatment called GnRH (gonadotropin-releasing hormone), which is for endometriosis. One of the side effects of this treatment is bone loss.
 
However, a definitive three-year study of more than 400 postmenopausal women concluded that ipriflavone did not prevent bone loss.
 
In addition, the compound was linked to lymphocytopenia (a reduction in lymphocytes) in a significant number of study participants. Lymphocytes are a type of white blood cell that helps the body fight infection.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;