Ipriflavone for Osteoporosis

Postmenopausal women often turn to ipriflavone, a synthetic form of isoflavone, as an alternative to hormone therapy for treating osteoporosis. But does it work? Further research is needed before we will know for sure, but a recent three-year study showed that ipriflavone for osteoporosis did not significantly prevent bone loss and could also lead to other medical conditions.

 
 

Ipriflavone for Osteoporosis: An Overview

Many postmenopausal women are looking for alternatives to hormone therapy, especially in light of research findings in 2003 from the Women's Health Initiative.
 
Phytoestrogens are naturally occurring plant compounds that are similar in some ways to estradiol, the most potent naturally occurring estrogen. However, phytoestrogens tend to have weaker effects than most estrogens, are not stored in the body, and can be easily broken down and eliminated.
 
Observational studies have found a lower prevalence of breast cancer, heart disease, and hip fracture rates among people living in places like Southeast Asia, where diets are typically high in phytoestrogens. As a result of these studies, a great deal of interest has been generated in the United States about the health benefits of phytoestrogens. According to the Food and Drug Administration (FDA), the sale of soy foods, a major source of phytoestrogens, has increased dramatically in the past decade.
 

Dietary Sources of Phytoestrogens

Phytoestrogens consist of more than 20 compounds and can be found in more than 300 plants, such as herbs, grains, and fruits. The three main classes of dietary phytoestrogens are:
 
  • Isoflavones
  • Lignans
  • Coumestans.
     
Isoflavones (genistein, daidzein, glycitein, and equol) are primarily found in soybeans and soy products, chickpeas, and other legumes. Ipriflavone is a synthetic version of isoflavone.
 
(Ipriflavone for Osteoporosis Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;