Osteoporosis Home > Actonel With Calcium Drug Interactions

When iron supplements, thyroid medications, or aspirin is taken with Actonel With Calcium, drug interactions may occur. Many of these interactions can make Actonel less effective; others increase the risk of side effects. To reduce your risk of Actonel With Calcium drug interactions, do not eat or drink anything (besides water) before taking the Actonel tablet and for 30 minutes after taking it.

Actonel With Calcium Drug Interactions: An Overview

(Actonel With Calcium has been discontinued by its manufacturer. Other forms of Actonel are still available. See the appropriate Actonel articles within eMedTV.com for more information about this medication.)


Actonel® With Calcium (risedronate and calcium) can potentially interact with a number of other medications. Many interactions can make Actonel With Calcium less effective, while others may increase the risk of side effects. Some of the medicines that may lead to drug interactions with Actonel With Calcium include:
  • Aspirin
  • Calcium products, including many antacids
  • Fluoroquinolone antibiotics, such as:
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
  • Thyroid medications, such as:
Food and beverages (other than water) can also interact with Actonel (the orange tablets that are taken once a week), preventing it from being absorbed into the body and making it less effective. The Actonel tablets should be taken with water in the morning on an empty stomach. Do not eat or drink anything (besides water) before taking Actonel and for 30 minutes after taking your Actonel dosage. On the other hand, the calcium tablets (the blue tablets that are taken on the other six days of the week) should be taken with food.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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