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In animal studies on Boniva and pregnancy, the medicine increased the risk of birth defects and difficult labor and delivery. It also increased the risk of death to the mother and offspring during labor. Since animals may not respond to drugs in the same way as humans, if you are taking Boniva and pregnancy occurs, you may still take the drug if your healthcare provider decides the benefits outweigh the risks.

Boniva and Pregnancy: An Overview

Boniva® (ibandronate sodium) is a prescription medication approved for the treatment and prevention of osteoporosis in postmenopausal women. It may not be safe for use during pregnancy, although the full risks are not known at this time.

Boniva and Pregnancy Category C

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but that do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
When given to pregnant rats and rabbits, Boniva increased the risk of difficult labor and delivery, as well as death of both the mothers and babies during labor. It also increased the risk of birth defects and developmental problems.
However, it is important to note that animals do not always respond to medicines the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.
If you are pregnant or are thinking of becoming pregnant while taking Boniva, let your healthcare provider know. He or she will consider both the benefits and risks of taking Boniva during pregnancy before making a recommendation for your particular situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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