Osteoporosis Home > Prolia and Breastfeeding

No human studies have been done on Prolia (denosumab) and breastfeeding, so it is not known if the drug passes through breast milk in women. Although it is likely that the medicine would be destroyed by the infant's digestive tract if Prolia did pass through breast milk, some animal studies suggest that the medication could interfere with a woman's ability to breastfeed.

Can Breastfeeding Women Take Prolia?

At this time, it is not known whether Prolia® (denosumab) passes through breast milk in humans. The drug's manufacturer does not recommend that women breastfeed while using Prolia. Therefore, you should talk with your healthcare provider before taking it if you are breastfeeding or thinking about breastfeeding.

What Does the Research Say?

No studies have been conducted on whether Prolia passes through breast milk in women. Even if the drug does pass through breast milk, it is likely to be destroyed and inactivated by the infant's digestive system because it is a delicate molecule that must be given by injection. However, until Prolia has been shown to be safe for breastfeeding women and their infants, it may be a good idea to avoid the drug while nursing.
Additionally, studies in mice that were genetically modified in such a way as to mimic the action of Prolia suggest that the medication could possibly interfere with the development of mammary glands and with lactation. It is possible that Prolia could interfere with a woman's ability to successfully breastfeed.

Talking With Your Healthcare Provider

You should discuss breastfeeding and Prolia with your healthcare provider. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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