Osteoporosis Home > Prolia Dosage

The recommended dosage of Prolia is the same for everyone -- one injection every six months. This injection should be administered by a healthcare provider and is given just under the skin in the abdomen (lower stomach area), upper arm, or upper thigh. It is also important to take calcium and vitamin D in combination with Prolia to help build bone.

An Introduction to Dosing With Prolia

There is only one recommended dosage of Prolia® (denosumab), regardless of your age, weight, or other medical conditions. As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Prolia Dosage for Osteoporosis

The recommended Prolia dose for osteoporosis treatment is 60 mg (1 mL) injected once every six months just under the skin in the abdomen (lower stomach area), upper arm, or upper thigh.
You should also be taking at least 1000 mg of calcium and 400 IU of vitamin D daily (or more, as your healthcare provider recommends).

General Information on Using Prolia

Some considerations for people receiving Prolia injections include the following:
  • The medication comes in an injectable form. It is injected once every six months just under the skin, in the abdomen (lower stomach), upper arm, or upper thigh.
  • Your healthcare provider should administer the injections (the product is not designed for at-home use).
  • You need to make sure that you get enough calcium and vitamin D while taking Prolia, as the medicine can deplete calcium levels in the blood. Prolia cannot help the body build bone without calcium and vitamin D.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.
  • Do not stop taking the drug without first discussing it with your healthcare provider.
  • If you are unsure about anything related to your dosage or Prolia dosing in general, please talk with your healthcare provider, nurse, or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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