Osteoporosis Home > Prolia Drug Interactions

Currently, it is unknown if Prolia will react with other medications. Based on clinical studies, it is believed that drug interactions may occur if Prolia is taken with medicines that suppress the immune system, such as cyclosporine, azathioprine, and corticosteroids. To avoid any complications, make sure your healthcare provider is aware of any other medications you are taking before receiving Prolia injections.

An Overview of Interactions With Prolia

Prolia® (denosumab) is a prescription osteoporosis medication given as an injection under the skin. At this time, there are no clearly established drug interactions with Prolia.
However, this does not guarantee that Prolia will not interact with other medications; it simply reflects the fact that not enough studies have been done to determine potential drug interactions.
Based on certain studies that indicated Prolia might increase the risk of infections (including serious infections), it is predicted that Prolia may interact with medications that suppress the immune system, such as:
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®)
Taking Prolia with other immunosuppressants could increase the risk of serious infections.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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