Osteoporosis Home > Prolia Side Effects

Back pain, skin reactions, and pain in an arm or leg are some of the more common side effects reported with Prolia. Reactions to the medication are usually minor and generally don't require treatment, but it is possible to develop serious side effects. Notify your healthcare provider immediately if you experience potentially serious problems, such as tooth problems, depression, or signs of an allergic reaction.

An Introduction to Prolia Side Effects

As with any medicine, Prolia® (denosumab) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects of this medication. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Prolia

Prolia has been studied thoroughly in clinical trials, in which the side effects occurring in a group of people taking the drug were documented and then compared to another group taking a placebo (an injection with no active ingredient). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group receiving the placebo. Both groups were instructed to take calcium and vitamin D.
In these studies, the most common side effects of Prolia included:
  • Back pain -- in up to 34.7 percent of people
  • Pain in an extremity (arm or leg) -- up to 11.7 percent
  • Skin reactions (such as rashes or eczema) -- up to 10.8 percent
  • Musculoskeletal pain (pain in muscles, bones, tendons, and ligaments) -- up to 7.6 percent
  • High cholesterol -- up to 7.2 percent
  • Bladder infections -- up to 5.9 percent
  • A spinning sensation (vertigo) -- up to 5 percent
  • Upper respiratory tract infections (such as the common cold) -- up to 4.9 percent
  • Swelling or water retention in the hands, arms, legs, or feet -- up to 4.9 percent
  • Sciatica -- up to 4.6 percent.
Other common Prolia side effects (occurring in 2 to 3.9 percent of people) included:
Keep in mind that for most of these common side effects, there was little difference between the group who received Prolia and the group who received the placebo. For instance, while 34.7 percent of people who were given Prolia experienced back pain, almost as many (34.6 percent) of the people who were given the placebo also experienced back pain.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.