Osteoporosis Home > Prolia Uses

Prolia is prescribed for treating osteoporosis. In particular, it is commonly used in postmenopausal women who have a high risk for fractures, as well as people who have tried other osteoporosis medications without success. It works by binding to certain cells and slowing the breakdown of bones. Possible "off-label" uses of Prolia include treating or preventing bone problems caused by cancer and osteoporosis caused by hormonal cancer treatments.

What Is Prolia Used For?

Prolia® (denosumab) is a prescription medication approved for the treatment of osteoporosis. It is given by injection twice a year. Specifically, Prolia is approved for use in the following groups of people:
  • Postmenopausal women with osteoporosis and who have a high risk for fractures
  • People who have tried other osteoporosis medications without success (or are intolerant of such medications).
Osteoporosis, which means "porous bone," is a disease characterized by low bone mass (bone thinning) that leads to fragile bones and an increased risk of fractures of the hip, spine, and wrist. Men as well as women are affected by this condition. Fortunately, osteoporosis is a disease that can be prevented and treated.
Common causes of osteoporosis include:
  • Age-related bone loss
  • Smoking
  • Alcohol abuse
  • Long-term corticosteroid use
  • Certain diseases.
Race and ethnicity may play a role in developing osteoporosis as well, but more research is needed to determine the connection.
Often, osteoporosis treatment is not started until a bone is broken, as there are usually no symptoms of the condition. However, treatment may be started earlier if osteoporosis is detected using a test (see Diagnosing Osteoporosis).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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