Osteoporosis Home > Reclast Side Effects

Commonly reported side effects of Reclast include headaches, dizziness, and bone pain. While side effects are generally minor and easily treated, some are potentially serious. If you experience serious Reclast side effects, such as unexplained swelling, difficulty breathing, or decreased urination, contact your healthcare provider right away. Fortunately, most people tolerate the drug without any problems.

An Introduction to Reclast Side Effects

As with any medicine, side effects are possible with Reclast® (zoledronic acid); however, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Reclast. Your healthcare provider can discuss a more complete list of Reclast side effects with you.)

Common Side Effects of Reclast

Reclast has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common side effects of Reclast included:
  • Joint pain -- in up to 23.8 percent of people
  • Fever -- up to 17.9 percent
  • High blood pressure (hypertension) -- up to 12.7 percent
  • Headaches -- up to 12.4 percent
  • Muscle pain -- up to 11.7 percent
  • Extremity pain -- up to 11.3 percent
  • Flu-like symptoms (such as fever, fatigue, and chills) -- up to 11 percent.
Other common Reclast side effects (occurring in 2 to 10 percent of people) included:
  • Dizziness
  • Bone pain, neck pain, shoulder pain, or chest pain
  • Lethargy
  • Swelling or fluid retention in the ankles or feet
  • Unusual sensations, such as burning or tingling
  • Abdominal pain
  • Bloating
  • Muscle stiffness
  • Arthritis
  • Diarrhea, nausea, vomiting, or stomach pain
  • Anemia
  • Weakness, fatigue, or a general ill feeling
  • A spinning sensation (vertigo)
  • Indigestion or heartburn
  • Muscle spasms
  • Dehydration
  • Loss of appetite.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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