Prolia Uses

How Does Prolia Work?

Prolia is a manufactured antibody that is designed specifically to bind to a protein known as receptor activator of nuclear factor kappa-B ligand (RANKL). Prolia prevents RANKL from activating the RANK receptor on the surface of osteoclast cells (as well as immature cells that will eventually become osteoclast cells). Osteoclasts are bone cells that are responsible for the breakdown of bone. Prolia slows down the formation, activity, and survival of osteoclast cells, thereby decreasing bone breakdown.
 

Can Children Use It?

Prolia is not approved for children. Talk to your healthcare provider about the benefits and risks of using Prolia in children. Based on animal studies, it is thought that this medication may decrease bone growth and tooth eruption in young children.
 

Off-Label Uses of Prolia

On occasion, your healthcare provider may recommend Prolia for something other than the uses discussed in this article. Off-label uses of Prolia include the treatment or prevention of the following conditions:
 
  • Complications due to cancer that has spread to the bones (another form of denosumab, sold under the name Xgeva®, is approved for this use)
  • Osteoporosis caused by certain hormonal cancer treatments (especially those used to treat breast or prostate cancer).
     
Lifestyle Changes to Help Your Bones

Prolia Medication Information

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