Reclast Warnings and Precautions

Before taking Reclast, warnings and precautions for the drug should be reviewed with your healthcare provider. Tell him or her if you may become pregnant while taking the drug or if you have problems absorbing vitamins and minerals from your diet. Reclast warnings and precautions also extend to people who have kidney disease, certain allergies, or conditions affecting the thyroid.

Reclast: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Reclast® (zoledronic acid) if you have:
  • Low blood calcium (hypocalcemia)
  • Kidney disease, including kidney failure (renal failure)
  • Hypoparathyroidism
  • A history of thyroid or parathyroid surgery
  • Problems absorbing vitamins and minerals from your diet
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding
  • Planning to have a dental procedure.
Make sure to tell your healthcare provider about all medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Reclast Warnings and Precautions

Warnings and precautions to be aware of prior to taking Reclast include the following:
  • In rare cases, bisphosphonates (including Reclast) have caused a condition called osteonecrosis of the jaw. This is a serious, possibly disfiguring, problem in which the bone of the jaw dies. Often, there are symptoms (such as pain, infection, or loosening of the teeth), but sometimes there are no symptoms until a person notices exposed bone. This problem is most common when bisphosphonates are given by IV. It seems that people who have dental procedures (such as a tooth extraction) are also at higher risk. Be sure to take good care of your mouth and teeth by seeing your dentist frequently. Let your healthcare provider know right away if you think you may have osteonecrosis of the jaw.


  • There have been rare reports of unusual broken thigh bones in people taking bisphosphonate medications like Reclast. It is not yet clear if the medications are to blame, since the fractures could simply be due to osteoporosis or other factors. These fractures typically were not caused by trauma or injury. Let your healthcare provider know if you have unexplained groin or thigh pain, as these are sometimes signs of thigh fractures. 


  • Reclast can cause low blood calcium. In order to help prevent this, you must take calcium and vitamin D, especially during the two weeks after your Reclast dose (see Reclast Dosage).
  • Reclast may not be recommended for people with moderate or severe kidney disease, as the medication can increase the risk of kidney damage. Your healthcare provider should check your kidney function (using a simple blood test) before each dose.
  • If you have a medical condition that affects calcium and vitamin D levels (such as thyroidism, parathyroidism, or nutritional disorders), you may need to be monitored more closely. In some cases, Reclast may not be recommended.
  • Bisphosphonates (including Reclast) can cause extreme muscle or bone pain. This usually goes away once the medication is stopped.
  • Reclast can potentially interact with a few other medications (see Reclast Drug Interactions).
  • Reclast is considered a pregnancy Category D medication. This means that it probably is not safe for use during pregnancy (see Reclast and Pregnancy).
  • It is not known whether Reclast passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Reclast and Breastfeeding).
Osteoporosis: Muscle Strengthening

Reclast for Paget's Disease

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